Unfortunately, no.
If you have your Shift4Shop store integrated with UPS, FedEx and DYMO|Endicia, you can print Shipping Labels right from the store using the Shipping Label Manager.
However, at this time, the Shipping Label manager can only print Domestic (meaning U.S.) Shipping labels.
For International Shipping labels, you will need to rely on either 3rd party Shipping Label applications (such as ShipWorks, ShipStation, Ready Shipper TrueShip, etc.) or by going through the individual shipping carrier directly.